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They stress the ability of the single-subject design to study indi-vidual subjects in depth through protracted pretreatment measures, to examine behaviorchanges over time, and to evaluate the effect of withdrawal of treatment on behavior. The mother was recruited and provided exposure information, but theoutcome measure was obtained on the child, during follow-up. Hence inflammatory-mediated chlorination of pyrimidine (cytosine) residuesin DNA may account for several DNA alterations observed in human tumors [12].A significant imbalance between ROS/RNS production and antioxidant defense can explainall findings associating with tumor growth and a state of high oxidative stress [13]. Moreover,an important intergenerational dimension is addedto the intervention when young family members par-ticipate in the creation of the video biography (Cohen,2002)

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